Cathepsin D antibody (Cleaved-Leu169)

Catalog No. ABIN7212452

The Rabbit Polyclonal anti-Cathepsin D antibody has been validated for WB and ELISA. It is suitable to detect Cathepsin D in samples from Human.

Quick Overview for Cathepsin D antibody (Cleaved-Leu169) (ABIN7212452)

Target: Cathepsin D (CTSD)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cathepsin D Antibody

Binding Specificity: AA 120-200, Cleaved-Leu169

Purpose: Cleaved-Cathepsin D HC (L169) Polyclonal Antibody

Specificity: Cleaved-Cathepsin D HC (L169) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D HC protein resulting from cleavage adjacent to L169.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Cathepsin D HC at AA range: 120-200

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: Cathepsin D HC

Background: Rabbit Anti-Cleaved-Cathepsin D HC (L169) Polyclonal Antibody,CTSD, CPSD, Cathepsin D,CTSD encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in CTSD play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.,Cathepsin D

Molecular Weight: observerd band 27kDa

Gene ID: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism