CCR2 antibody (AA 250-330)

Catalog No. ABIN7218828

The Rabbit Polyclonal anti-CCR2 antibody (ABIN7218828) specifically detects CCR2 in WB, ELISA and IF. The antibody is reactive with Mouse and Rat samples.

Quick Overview for CCR2 antibody (AA 250-330) (ABIN7218828)

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-CCR2 Antibody

Binding Specificity: AA 250-330

Purpose: Rabbit Anti-CKR-2 Polyclonal Antibody

Specificity: CKR-2 Polyclonal Antibody detects endogenous levels of CKR-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human CKR-2 at AA range: 250-330

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CCR2

Target: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Alternative Name: CKR-2

Background: CCR2, CMKBR2, C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, CD antigen CD192CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include idiopathic anterior uveitis and cd3zeta deficiency. Among its related pathways are Signaling by GPCR and A-beta Pathways: uptake and Degradation. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CCR9. eceptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. hemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Molecular Weight: 46kD

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process