CLP1 antibody (AA 50-130)

Catalog No. ABIN7227952

This Rabbit Polyclonal antibody specifically detects CLP1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CLP1 antibody (AA 50-130) (ABIN7227952)

Target: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CLP1 Antibody

Binding Specificity: AA 50-130

Purpose: Rabbit Anti-CLP1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CLP1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CLP1 protein at AA range: 50-130

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CLP1

Target: CLP1 (Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))

Alternative Name: CLP1

Background: Polyribonucleotide 5'-hydroxyl-kinase Clp1, Polyadenylation factor Clp1, Polynucleotide kinase Clp1, Pre-mRNA cleavage complex II protein Clp1CLP1 (Cleavage And Polyadenylation Factor I Subunit 1) encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in CLP1 are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for CLP1.

Molecular Weight: 46kD

Gene ID: 10978

UniProt: Q92989

Pathways: Ribonucleoprotein Complex Subunit Organization