COL2 antibody

Catalog No. ABIN7212410

This Mouse Monoclonal antibody specifically detects COL2 in IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for COL2 antibody (ABIN7212410)

Target: COL2 (Collagen, Type II (COL2))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This COL2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 7F9

Product Details anti-COL2 Antibody

Purpose: Mouse Anti-Collagen II Mouse Monoclonal Antibody (7F9)

Specificity: The antibody detects endogenous Collagen II protein .

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic Peptide of Collagen II

Isotype: IgG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for COL2

Target: COL2 (Collagen, Type II (COL2))

Alternative Name: Collagen II

Background: Collagen alpha-1(II) chain, Alpha-1 type II collagenCOL2A1 (collagen type II alpha 1 chain) encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in COL2A1 are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for COL2A1.

Molecular Weight: 142kD

Gene ID: 1280

UniProt: P02458