CNGA1 antibody (AA 370-450)

Catalog No. ABIN7219474

The Rabbit Polyclonal anti-CNGA1 antibody (ABIN7219474) specifically detects CNGA1 in ELISA and WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for CNGA1 antibody (AA 370-450) (ABIN7219474)

Target: CNGA1 (Cyclic Nucleotide Gated Channel alpha 1 (CNGA1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNGA1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-CNGA1 Antibody

Binding Specificity: AA 370-450

Purpose: Rabbit Anti-CNG-1 Polyclonal Antibody

Specificity: CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CNG-1 at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CNGA1

Target: CNGA1 (Cyclic Nucleotide Gated Channel alpha 1 (CNGA1))

Alternative Name: CNG-1

Background: CNGA1, CNCG, CNCG1, cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated cation channel 1, Cyclic nucleotide-gated channel alpha-1, CNG channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel, photoreceptor, Rod photoreceptor cGThe cyclic nucleotide gated channel alpha 1 encoded by CNGA1 is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 80kD

Gene ID: 1259

UniProt: P29973

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction, Asymmetric Protein Localization