Cyclin B3 antibody

Catalog No. ABIN7227656

The Rabbit Polyclonal anti-Cyclin B3 antibody is suitable to detect Cyclin B3 in samples from Mouse and Human. It has been validated for ELISA and WB.

Quick Overview for Cyclin B3 antibody (ABIN7227656)

Target: Cyclin B3 (CCNB3)

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin B3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-Cyclin B3 Antibody

Purpose: Rabbit Anti-CCNB3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of CCNB3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human CCNB3 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Cyclin B3

Target: Cyclin B3 (CCNB3)

Alternative Name: CCNB3

Background: G2/mitotic-specific cyclin-B3The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 153kD

Gene ID: 85417

UniProt: Q8WWL7

Pathways: Cell Division Cycle, Chromatin Binding