DMP1 antibody (AA 430-510)

Catalog No. ABIN7228256

The Rabbit Polyclonal anti-DMP1 antibody (ABIN7228256) specifically detects DMP1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for DMP1 antibody (AA 430-510) (ABIN7228256)

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-DMP1 Antibody

Binding Specificity: AA 430-510

Purpose: Rabbit Anti-DMP1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DMP1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human DMP1 protein at AA range: 430-510

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DMP1

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Alternative Name: DMP1

Background: Dentin matrix acidic phosphoprotein 1, DMP-1, Dentin matrix protein 1Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. DMP1 structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for DMP1.

Molecular Weight: 56kD

Gene ID: 1758

UniProt: Q13316