Desmocollin 3 antibody

Catalog No. ABIN7228302

This Rabbit Polyclonal antibody specifically detects Desmocollin 3 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Desmocollin 3 antibody (ABIN7228302)

Target: Desmocollin 3 (DSC3)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Desmocollin 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Desmocollin 3 Antibody

Purpose: Rabbit Anti-DSC3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DSC3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human DSC3 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Desmocollin 3

Target: Desmocollin 3 (DSC3)

Alternative Name: DSC3

Background: Desmocollin-3, Cadherin family member 3, Desmocollin-4, HT-CPThe protein encoded by DSC3 gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Molecular Weight: 98kD

Gene ID: 1825

UniProt: Q14574