Diazepam Binding Inhibitor antibody (C-Term)

Catalog No. ABIN7217936

The Rabbit Polyclonal anti-Diazepam Binding Inhibitor antibody (ABIN7217936) specifically detects Diazepam Binding Inhibitor in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Diazepam Binding Inhibitor antibody (C-Term) (ABIN7217936)

Target: Diazepam Binding Inhibitor (DBI)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Diazepam Binding Inhibitor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Diazepam Binding Inhibitor Antibody

Binding Specificity: C-Term

Purpose: Rabbit Anti-ACBP Polyclonal Antibody

Specificity: ACBP Polyclonal Antibody detects endogenous levels of ACBP protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human ACBP

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Diazepam Binding Inhibitor

Target: Diazepam Binding Inhibitor (DBI)

Alternative Name: ACBP

Background: DBI, Acyl-CoA-binding protein, ACBP, Diazepam-binding inhibitor, DBI, Endozepine, EPDBI encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 10kD

Gene ID: 1622

UniProt: P07108