DOK7 antibody (AA 10-90)

Catalog No. ABIN7221244

The Rabbit Polyclonal anti-DOK7 antibody (ABIN7221244) specifically detects DOK7 in WB, ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for DOK7 antibody (AA 10-90) (ABIN7221244)

Target: DOK7 (Docking Protein 7 (DOK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-DOK7 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-Dok-7 Polyclonal Antibody

Specificity: Dok-7 Polyclonal Antibody detects endogenous levels of Dok-7 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Dok-7 at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DOK7

Target: DOK7 (Docking Protein 7 (DOK7))

Alternative Name: Dok-7

Background: DOK7, C4orf25, Protein Dok-7, Downstream of tyrosine kinase 7The docking protein 7 encoded by DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in DOK7 are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

Molecular Weight: 60kD

Gene ID: 285489

UniProt: Q18PE1

Pathways: Skeletal Muscle Fiber Development