Dopamine d2 Receptor antibody (AA 170-250)

Catalog No. ABIN7228296

The Rabbit Polyclonal anti-Dopamine d2 Receptor antibody (ABIN7228296) specifically detects Dopamine d2 Receptor in WB and ELISA. The antibody is reactive with Human and Rat samples.

Quick Overview for Dopamine d2 Receptor antibody (AA 170-250) (ABIN7228296)

Target: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dopamine d2 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Dopamine d2 Receptor Antibody

Binding Specificity: AA 170-250

Purpose: Rabbit Anti-DRD2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DRD2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human DRD2 protein at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Dopamine d2 Receptor

Target: Dopamine d2 Receptor (DRD2) (Dopamine Receptor D2 (DRD2))

Alternative Name: DRD2

Background: D, 2dopamine receptor, Dopamine D2 receptorDRD2 encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in DRD2 causes myoclonus dystonia, other mutations have been associated with schizophrenia. Alternative splicing of DRD2 results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.

Molecular Weight: 48kD

Gene ID: 1813

UniProt: P14416

Pathways: Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity