NEIL2 antibody

Catalog No. ABIN7229952

The Rabbit Polyclonal anti-NEIL2 antibody is suitable to detect NEIL2 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for NEIL2 antibody (ABIN7229952)

Target: NEIL2 (Endonuclease 8-like 2 (NEIL2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEIL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NEIL2 Antibody

Purpose: NEIL2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NEIL2 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human NEIL2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for NEIL2

Target: NEIL2 (Endonuclease 8-like 2 (NEIL2))

Alternative Name: NEIL2

Background: Rabbit Anti-NEIL2 Polyclonal Antibody,Endonuclease 8-like 2, DNA glycosylase/AP lyase Neil2, DNA-(apurinic or apyrimidinic site) lyase Neil2, Endonuclease VIII-like 2, Nei homolog 2, NEH2, Nei-like protein 2,NEIL2 encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified.,NEIL2

Molecular Weight: observerd band 36kDa

Gene ID: 252969

UniProt: Q969S2

Pathways: DNA Damage Repair