Endothelin 1 antibody (Internal Region)

Catalog No. ABIN7217844

This anti-Endothelin 1 antibody is a Rabbit Polyclonal antibody detecting Endothelin 1 in WB and ELISA. Suitable for Human.

Quick Overview for Endothelin 1 antibody (Internal Region) (ABIN7217844)

Target: Endothelin 1 (EDN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Endothelin 1 Antibody

Binding Specificity: Internal Region

Purpose: ET-1 Polyclonal Antibody

Specificity: ET-1 Polyclonal Antibody detects endogenous levels of ET-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human ET-1

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Endothelin 1

Target: Endothelin 1 (EDN1)

Alternative Name: ET-1

Background: Rabbit Anti-ET-1 Polyclonal Antibody,EDN1, Endothelin-1, Preproendothelin-1, PPET1,EDN1 encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.,Endothelin-1

Molecular Weight: observerd band 25kDa

Gene ID: 1906

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size