FAM111B antibody (AA 250-330)

Catalog No. ABIN7221972

This Rabbit Polyclonal antibody specifically detects FAM111B in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for FAM111B antibody (AA 250-330) (ABIN7221972)

Target: FAM111B (Family with Sequence Similarity 111, Member B (FAM111B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM111B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FAM111B Antibody

Binding Specificity: AA 250-330

Purpose: Rabbit Anti-FAM111B Polyclonal Antibody

Specificity: FAM111B Polyclonal Antibody detects endogenous levels of FAM111B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human FAM111B at AA range: 250-330

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:200,ELISA 1:5000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FAM111B

Target: FAM111B (Family with Sequence Similarity 111, Member B (FAM111B))

Alternative Name: FAM111B

Background: FAM111B, CANP, Protein FAM111B, Cancer-associated nucleoproteinFAM111B encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin-like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.

Gene ID: 374393

UniProt: Q6SJ93