FANCM antibody

Catalog No. ABIN7228482

The Rabbit Polyclonal anti-FANCM antibody is suitable to detect FANCM in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for FANCM antibody (ABIN7228482)

Target: FANCM (Fanconi Anemia Complementation Group M (FANCM))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCM antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FANCM Antibody

Purpose: Rabbit Anti-FANCM Polyclonal Antibody

Specificity: The antibody detects endogenous levels of FANCM protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human FANCM protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FANCM

Target: FANCM (Fanconi Anemia Complementation Group M (FANCM))

Alternative Name: FANCM

Background: Fanconi anemia group M protein, Protein FACM, ATP-dependent RNA helicase FANCM Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef orthologThe Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. FANCM (Fanconi Anemia Complementation Group M) is a Protein Coding gene. Diseases associated with FANCM include Fanconi Anemia, Complementation Group A and Fancm-Related Fanconi Anemia. Among its related pathways are Fanconi anemia pathway and DNA Double-Strand Break Repair.

Molecular Weight: 225kD

Gene ID: 57697

UniProt: Q8IYD8

Pathways: DNA Damage Repair