FAT1 antibody (AA 1140-1220)

Catalog No. ABIN7228488

This Rabbit Polyclonal antibody specifically detects FAT1 in IHC and IF. It exhibits reactivity toward Human.

Quick Overview for FAT1 antibody (AA 1140-1220) (ABIN7228488)

Target: FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAT1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FAT1 Antibody

Binding Specificity: AA 1140-1220

Purpose: Rabbit Anti-FAT1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of FAT1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human FAT1 protein at AA range: 1140-1220

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FAT1

Target: FAT1 (FAT Tumor Suppressor Homolog 1 (FAT1))

Alternative Name: FAT1

Background: Protocadherin Fat 1, Cadherin family member 7, Cadherin-related tumor suppressor homolog, Protein fat homolog, Protocadherin Fat 1, nuclear formFAT1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. FAT1 product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, FAT1 product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. FAT1 is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.

Molecular Weight: 504kD

Gene ID: 2195

UniProt: Q14517