FGFR1OP antibody (AA 310-390)

Catalog No. ABIN7214926

The Rabbit Polyclonal anti-FGFR1OP antibody is suitable to detect FGFR1OP in samples from Human, Mouse and Rat. It has been validated for WB, IHC, ELISA and IF.

Quick Overview for FGFR1OP antibody (AA 310-390) (ABIN7214926)

Target: FGFR1OP (FGFR1 Oncogene Partner (FGFR1OP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR1OP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-FGFR1OP Antibody

Binding Specificity: AA 310-390

Purpose: Rabbit Anti-FOP Polyclonal Antibody

Specificity: FOP Polyclonal Antibody detects endogenous levels of FOP protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human FOP at AA range: 310-390

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FGFR1OP

Target: FGFR1OP (FGFR1 Oncogene Partner (FGFR1OP))

Alternative Name: FOP

Background: FGFR1OP, FOP, FGFR1 oncogene partnerFGFR1OP encodes a largely hydrophilic centrosomal protein, FGFR1 oncogene partner, that is required for anchoring microtubules to subcellular structures. A t(6,8)(q27,p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified.

Molecular Weight: 43kD

Gene ID: 11116

UniProt: O95684

Pathways: M Phase, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome