Fibulin 5 antibody (AA 140-220)

Catalog No. ABIN7214900

The Rabbit Polyclonal anti-Fibulin 5 antibody is suitable to detect Fibulin 5 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Fibulin 5 antibody (AA 140-220) (ABIN7214900)

Target: Fibulin 5 (FBLN5)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibulin 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Fibulin 5 Antibody

Binding Specificity: AA 140-220

Purpose: Rabbit Anti-Fibulin-5 Polyclonal Antibody

Specificity: Fibulin-5 Polyclonal Antibody detects endogenous levels of Fibulin-5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Fibulin-5 at AA range: 140-220

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Fibulin 5

Target: Fibulin 5 (FBLN5)

Alternative Name: Fibulin-5

Background: FBLN5, DANCE, Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50Fibulin-5 encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

Molecular Weight: 50kD

Gene ID: 10516

UniProt: Q9UBX5

Pathways: SARS-CoV-2 Protein Interactome