FIL1L antibody (AA 30-110)

Catalog No. ABIN7214602

The Rabbit Polyclonal anti-FIL1L antibody is suitable to detect FIL1L in samples from Human and Mouse. It has been validated for ELISA and WB.

Quick Overview for FIL1L antibody (AA 30-110) (ABIN7214602)

Target: FIL1L (FILIP1L) (Filamin A Interacting Protein 1-Like (FILIP1L))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIL1L antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-FIL1L Antibody

Binding Specificity: AA 30-110

Purpose: Rabbit Anti-DOC-1 Polyclonal Antibody

Specificity: DOC-1 Polyclonal Antibody detects endogenous levels of DOC-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human DOC-1 at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FIL1L

Target: FIL1L (FILIP1L) (Filamin A Interacting Protein 1-Like (FILIP1L))

Alternative Name: DOC-1

Background: CDK2AP1, CDKAP1, DOC1, Cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Deleted in oral cancer 1, DOC-1, Putative oral cancer suppressorCyclin dependent kinase 2 associated protein 1encoded by CDK2AP1 is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 20kD

Gene ID: 8099

UniProt: O14519