GRIK1 antibody (AA 10-90)

Catalog No. ABIN7221310

This Rabbit Polyclonal antibody specifically detects GRIK1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GRIK1 antibody (AA 10-90) (ABIN7221310)

Target: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GRIK1 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-GluR-5 Polyclonal Antibody

Specificity: GluR-5 Polyclonal Antibody detects endogenous levels of GluR-5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human GluR-5 at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GRIK1

Target: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Alternative Name: GluR-5

Background: GRIK1, GLUR5, Glutamate receptor, ionotropic kainate 1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for GRIK1.

Molecular Weight: 100kD

Gene ID: 2897

UniProt: P39086

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity