GRM2 antibody (AA 210-290)

Catalog No. ABIN7221364

The Rabbit Polyclonal anti-GRM2 antibody is suitable to detect GRM2 in samples from Human, Rat and Mouse. It has been validated for ELISA, IHC and IF.

Quick Overview for GRM2 antibody (AA 210-290) (ABIN7221364)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GRM2 Antibody

Binding Specificity: AA 210-290

Purpose: Rabbit Anti-mGluR2 Polyclonal Antibody

Specificity: MGluR2 Polyclonal Antibody detects endogenous levels of mGluR2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human mGluR2 at AA range: 210-290

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Alternative Name: mGluR2

Background: GRM2, GPRC1B, MGLUR2, Metabotropic glutamate receptor 2, mGluR2L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for GRM2.

Gene ID: 2912

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport