GRM7 antibody (AA 320-400)

Catalog No. ABIN7221374

The Rabbit Polyclonal anti-GRM7 antibody (ABIN7221374) specifically detects GRM7 in WB, ELISA and IHC. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for GRM7 antibody (AA 320-400) (ABIN7221374)

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-GRM7 Antibody

Binding Specificity: AA 320-400

Purpose: Rabbit Anti-mGluR7 Polyclonal Antibody

Specificity: MGluR7 Polyclonal Antibody detects endogenous levels of mGluR7 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human mGluR7 at AA range: 320-400

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GRM7

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Alternative Name: mGluR7

Background: GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7, mGluR7L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for GRM7.

Molecular Weight: 102kD

Gene ID: 2917

UniProt: Q14831

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour