GZMH antibody (AA 30-110)

Catalog No. ABIN7221430

The Rabbit Polyclonal anti-GZMH antibody (ABIN7221430) specifically detects GZMH in WB, IHC, ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for GZMH antibody (AA 30-110) (ABIN7221430)

Target: GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-GZMH Antibody

Binding Specificity: AA 30-110

Purpose: Rabbit Anti-Granzyme H Polyclonal Antibody

Specificity: Granzyme H Polyclonal Antibody detects endogenous levels of Granzyme H protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Granzyme H at AA range: 30-110

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GZMH

Target: GZMH (Granzyme H (Cathepsin G-Like 2, Protein H-CCPX) (GZMH))

Alternative Name: Granzyme H

Background: GZMH, CGL2, CTSGL2, Granzyme H, CCP-X, Cathepsin G-like 2, CTSGL2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C, CSP-CGZMH encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. Granzyme H is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. GZMH is present in a gene cluster with another member of the granzyme subfamily on chromosome 14.

Molecular Weight: 23kD

Gene ID: 2999

UniProt: P20718