HBEGF antibody (AA 130-210)

Catalog No. ABIN7228858

This Rabbit Polyclonal antibody specifically detects HBEGF in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HBEGF antibody (AA 130-210) (ABIN7228858)

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HBEGF antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HBEGF Antibody

Binding Specificity: AA 130-210

Purpose: HBEGF Polyclonal Antibody

Specificity: The antibody detects endogenous levels of HBEGF protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human HBEGF protein at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for HBEGF

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Alternative Name: HBEGF

Background: Rabbit Anti-HBEGF Polyclonal Antibody,Diphtheria toxin receptor, DT-R,HBEGF (Heparin Binding EGF Like Growth Factor) is a Protein Coding gene. Diseases associated with HBEGF include Diphtheria and Bladder Disease. Among its related pathways are RET signaling and p70S6K Signaling. GO annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is AREG. Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.,HBEGF

Molecular Weight: observerd band 22kDa

Gene ID: 1839

UniProt: Q99075

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway