HEXB antibody (AA 450-530)

Catalog No. ABIN7221476

The Rabbit Polyclonal anti-HEXB antibody (ABIN7221476) specifically detects HEXB in WB, ELISA, IHC (p) and IF. The antibody is reactive with Human samples.

Quick Overview for HEXB antibody (AA 450-530) (ABIN7221476)

Target: HEXB (Hexosaminidase B (Beta Polypeptide) (HEXB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEXB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-HEXB Antibody

Binding Specificity: AA 450-530

Purpose: Hexb Polyclonal Antibody

Specificity: Hexb Polyclonal Antibody detects endogenous levels of Hexb protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Hexb at AA range: 450-530

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for HEXB

Target: HEXB (Hexosaminidase B (Beta Polypeptide) (HEXB))

Alternative Name: Hexb

Background: Rabbit Anti-Hexb Polyclonal Antibody,HEXB, HCC7, Beta-hexosaminidase subunit beta, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, Cervical cancer proto-oncogene 7 protein, HCC-7, N-acetyl-beta-glucosaminidase subunit beta,Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for HEXB.,Beta-hexosaminidase subunit beta

Molecular Weight: observerd band 63kDa

Gene ID: 3074

UniProt: P07686

Pathways: Sensory Perception of Sound, Glycosaminoglycan Metabolic Process