HRS (HRS) (pTyr216) antibody

Catalog No. ABIN7212990

This Rabbit Polyclonal antibody specifically detects in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for HRS (HRS) (pTyr216) antibody (ABIN7212990)

Target: HRS

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Product Details

Binding Specificity: pTyr216

Purpose: Hrs (phospho Tyr216) Polyclonal Antibody

Specificity: Phospho-Hrs (Y216) Polyclonal Antibody detects endogenous levels of Hrs protein only when phosphorylated at Y216.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Hrs Phospho-Tyr216

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: HRS

Alternative Name: Hrs

Background: Rabbit Anti-Hrs (phospho Tyr216) Polyclonal Antibody,HGS, HRS, Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110,Hepatocyte growth factor-regulated tyrosine kinase substrate encoded by HGS regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. Hepatocyte growth factor-regulated tyrosine kinase substrate sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.,Hepatocyte growth factor-regulated tyrosine kinase substrate

Molecular Weight: observerd band 115kDa

Gene ID: 9146

UniProt: O14964

Pathways: CXCR4-mediated Signaling Events, EGFR Downregulation