IBTK antibody (AA 410-490)

Catalog No. ABIN7229004

The Rabbit Polyclonal anti-IBTK antibody is suitable to detect IBTK in samples from Human. It has been validated for WB and ELISA.

Quick Overview for IBTK antibody (AA 410-490) (ABIN7229004)

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IBTK antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IBTK Antibody

Binding Specificity: AA 410-490

Purpose: IBTK Polyclonal Antibody

Specificity: The antibody detects endogenous levels of IBTK protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human IBTK protein at AA range: 410-490

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Alternative Name: IBTK

Background: Rabbit Anti-IBTK Polyclonal Antibody,Inhibitor of Bruton tyrosine kinase, IBtk,IBTK (Inhibitor Of Bruton Tyrosine Kinase) is a Protein Coding gene. Diseases associated with IBTK include Agammaglobulinemia. Among its related pathways are B cell receptor signaling pathway (KEGG). Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by IBTK binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. IBTK has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,IBTK

Molecular Weight: observerd band 148kDa

Gene ID: 25998

UniProt: Q9P2D0