INSIG2 antibody (AA 40-120)

Catalog No. ABIN7229148

This Rabbit Polyclonal antibody specifically detects INSIG2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for INSIG2 antibody (AA 40-120) (ABIN7229148)

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSIG2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-INSIG2 Antibody

Binding Specificity: AA 40-120

Purpose: Rabbit Anti-INSI2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of INSI2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human INSI2 protein at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for INSIG2

Target: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Alternative Name: INSI2

Background: Insulin-induced gene 2 protein, INSIG-2INSIG2 (Insulin Induced Gene 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. The protein encoded by INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.

Molecular Weight: 24kD

Gene ID: 51141

UniProt: Q9Y5U4

Pathways: ER-Nucleus Signaling