ITGA7 antibody (Cleaved-Glu959)

Catalog No. ABIN7212524

The Rabbit Polyclonal anti-ITGA7 antibody is suitable to detect ITGA7 in samples from Human and Monkey. It has been validated for WB and ELISA.

Quick Overview for ITGA7 antibody (Cleaved-Glu959) (ABIN7212524)

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ITGA7 Antibody

Binding Specificity: AA 910-990, Cleaved-Glu959

Purpose: Rabbit Anti-Cleaved-Integrin α7 LC (E959) Polyclonal Antibody

Specificity: Cleaved-Integrin α7 LC (E959) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α7 LC protein resulting from cleavage adjacent to E959.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Integrin alpha7 LC at AA range: 910-990

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ITGA7

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Alternative Name: Integrin alpha7 LC

Background: ITGA7, Integrin alpha-7The protein encoded by ITGA7 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis.Integrin subunit alpha 7 functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in ITGA7 are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for ITGA7.

Molecular Weight: 25kD

Gene ID: 3679

UniProt: Q13683

Pathways: Integrin Complex