Integrin beta 3 antibody (pTyr785)

Catalog No. ABIN7213194

The Rabbit Polyclonal anti-Integrin beta 3 antibody is suitable to detect Integrin beta 3 in samples from Human, Mouse and Rat. It has been validated for IHC, ELISA and IF.

Quick Overview for Integrin beta 3 antibody (pTyr785) (ABIN7213194)

Target: Integrin beta 3 (ITGB3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Integrin beta 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-Integrin beta 3 Antibody

Binding Specificity: pTyr785

Purpose: Rabbit Anti-Integrin β3 (phospho Tyr785) Polyclonal Antibody

Specificity: Phospho-Integrin β3 (Y785) Polyclonal Antibody detects endogenous levels of Integrin β3 protein only when phosphorylated at Y785.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Integrin beta3 Phospho-Tyr785

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF/ICC1:50-300,ELISA 1:2000-20000,IHC 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: Integrin beta3

Background: ITGB3, GP3A, Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD antigen CD61The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Molecular Weight: 87kD

Gene ID: 3690

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex