IFNAR1 antibody (pTyr466)

Catalog No. ABIN7221686

This Rabbit Polyclonal antibody specifically detects IFNAR1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for IFNAR1 antibody (pTyr466) (ABIN7221686)

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNAR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IFNAR1 Antibody

Binding Specificity: pTyr466

Purpose: IFN-α/βRα (phospho Tyr466) Polyclonal Antibody

Specificity: Phospho-IFN-α/βRα (Y466) Polyclonal Antibody detects endogenous levels of IFN-α/βRα protein only when phosphorylated at Y466.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human IFN-alpha/betaRalpha Phospho-Tyr466

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Alternative Name: IFN-alpha/betaRalpha

Background: Rabbit Anti-IFN-α/βRα (phospho Tyr466) Polyclonal Antibody,IFNAR1, IFNAR, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1,Interferon alpha and beta receptor subunit 1 encoded by IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.,Interferon alpha

Molecular Weight: observerd band 63kDa

Gene ID: 3454

UniProt: P17181

Pathways: JAK-STAT Signaling, Hepatitis C