IL12RB1 antibody (Internal Region)

Catalog No. ABIN7218730

The Rabbit Polyclonal anti-IL12RB1 antibody has been validated for WB and ELISA. It is suitable to detect IL12RB1 in samples from Human.

Quick Overview for IL12RB1 antibody (Internal Region) (ABIN7218730)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL12RB1 Antibody

Binding Specificity: Internal Region

Purpose: IL-12Rβ1 Polyclonal Antibody

Specificity: IL-12Rβ1 Polyclonal Antibody detects endogenous levels of IL-12Rβ1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human IL-12Rbeta1

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: IL-12Rbeta1

Background: Rabbit Anti-IL-12Rβ1 Polyclonal Antibody,IL12RB1, IL12R, IL12RB, Interleukin-12 receptor subunit beta-1, IL-12 receptor subunit beta-1, IL-12R subunit beta-1, IL-12R-beta-1, IL-12RB1, IL-12 receptor beta component, CD212,The interleukin 12 receptor subunit beta 1 encoded by IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.,Interleukin-12 receptor subunit beta-1

Molecular Weight: observerd band 73kDa

Gene ID: 3594

UniProt: P42701

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation