IL21 Receptor antibody

Catalog No. ABIN7229112

This Rabbit Polyclonal antibody specifically detects IL21 Receptor in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for IL21 Receptor antibody (ABIN7229112)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL21 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL21 Receptor Antibody

Purpose: Rabbit Anti-IL21R Polyclonal Antibody

Specificity: The antibody detects endogenous levels of IL21R protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human IL21R protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: IL21R

Background: Interleukin-21 receptor, IL-21 receptor, IL-21R, Novel interleukin receptor, CD_antigen: CD360Interleukin 21 Receptor encoded by IL21R is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Molecular Weight: 59kD

Gene ID: 50615

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling