KISS1 antibody

Catalog No. ABIN7229292

This Rabbit Polyclonal antibody specifically detects KISS1 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for KISS1 antibody (ABIN7229292)

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KISS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KISS1 Antibody

Purpose: Rabbit Anti-KISS1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of KISS1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human KISS1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for KISS1

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Alternative Name: KISS1

Background: Metastasis-suppressor KiSS-1, Kisspeptin-1KISS1 gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.

Molecular Weight: 15kD

Gene ID: 3814

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion