Krs-1/2 antibody

Catalog No. ABIN7224530

This Rabbit Polyclonal antibody specifically detects Krs-1/2 in ELISA, WB, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Krs-1/2 antibody (ABIN7224530)

Target: Krs-1/2

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details

Purpose: Rabbit Anti-Krs-1/2 Polyclonal Antibody

Specificity: Krs-1/2 Polyclonal Antibody detects endogenous levels of Krs-1/2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Krs-1/2 around the non-phosphorylation site of T183

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details

Target: Krs-1/2

Background: STK3, KRS1, MST2, Serine/threonine-protein kinase 3, Mammalian STE20-like protein kinase 2, MST-2, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, STK4, KRS2, MST1, Serine/threonine-protein kinase 4, Mammalian STE20-like protSTK3 (serine/threonine kinase 3) encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for STK3.

Molecular Weight: 56kD

Gene ID: 6788, 6789

UniProt: Q13188, Q13043