LMTK2 antibody (AA 620-700)

Catalog No. ABIN7220554

This Rabbit Polyclonal antibody specifically detects LMTK2 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for LMTK2 antibody (AA 620-700) (ABIN7220554)

Target: LMTK2 (Lemur tyrosine Kinase 2 (LMTK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMTK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-LMTK2 Antibody

Binding Specificity: AA 620-700

Purpose: Rabbit Anti-KPI-2 Polyclonal Antibody

Specificity: KPI-2 Polyclonal Antibody detects endogenous levels of KPI-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human KPI-2 at AA range: 620-700

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LMTK2

Target: LMTK2 (Lemur tyrosine Kinase 2 (LMTK2))

Alternative Name: KPI-2

Background: LMTK2, AATYK2, BREK, KIAA1079, KPI2, LMR2, Serine/threonine-protein kinase LMTK2, Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, hBREK, CDK5/p35-regulated kinase, CPRK, Kinase/phosphatase/inhibitor 2, Lemur tyrosine kinase 2The lemur tyrosine kinase 2 encoded by LMTK2 belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.

Molecular Weight: 164kD

Gene ID: 22853

UniProt: Q8IWU2

Pathways: RTK Signaling, Neurotrophin Signaling Pathway