LAIR1 antibody (Internal Region)

Catalog No. ABIN7218770

The Rabbit Polyclonal anti-LAIR1 antibody (ABIN7218770) specifically detects LAIR1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LAIR1 antibody (Internal Region) (ABIN7218770)

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAIR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LAIR1 Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-CD305 Polyclonal Antibody

Specificity: CD305 Polyclonal Antibody detects endogenous levels of CD305 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CD305

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LAIR1

Target: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Alternative Name: CD305

Background: LAIR1, CD305, Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305The leukocyte associated immunoglobulin like receptor 1 encoded by LAIR1 is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13. called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants.

Molecular Weight: 32kD

Gene ID: 3903

UniProt: Q6GTX8