LAG3 antibody (Internal Region)

Catalog No. ABIN7218480

This Rabbit Polyclonal antibody specifically detects LAG3 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LAG3 antibody (Internal Region) (ABIN7218480)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAG3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LAG3 Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-CD223 Polyclonal Antibody

Specificity: CD223 Polyclonal Antibody detects endogenous levels of CD223 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CD223

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Alternative Name: CD223

Background: LAG3, FDC, Lymphocyte activation gene 3 protein, LAG-3, Protein FDC, CD223Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Molecular Weight: 57kD

Gene ID: 3902

UniProt: P18627

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints