MAML2 antibody (AA 10-90)

Catalog No. ABIN7229558

The Rabbit Polyclonal anti-MAML2 antibody (ABIN7229558) specifically detects MAML2 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for MAML2 antibody (AA 10-90) (ABIN7229558)

Target: MAML2 (Mastermind-Like 2 (MAML2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAML2 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-MAML2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MAML2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MAML2 protein at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MAML2

Target: MAML2 (Mastermind-Like 2 (MAML2))

Alternative Name: MAML2

Background: Mastermind-like protein 2, Mam-2The protein encoded by MAML2 (Mastermind Like Transcriptional Coactivator 2) is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of MAML2 have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.

Molecular Weight: 127kD

Gene ID: 84441

UniProt: Q8IZL2