MCF2L antibody

Catalog No. ABIN7229596

The Rabbit Polyclonal anti-MCF2L antibody (ABIN7229596) specifically detects MCF2L in WB and ELISA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MCF2L antibody (ABIN7229596)

Target: MCF2L (MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCF2L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MCF2L Antibody

Purpose: Rabbit Anti-MCF2L Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MCF2L protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MCF2L protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MCF2L

Target: MCF2L (MCF.2 Cell Line Derived Transforming Sequence-Like (MCF2L))

Alternative Name: MCF2L

Background: Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like proteinMCF2L encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. MCF2L (MCF. Cell Line Derived Transforming Sequence Like) is a Protein Coding gene. Diseases associated with MCF2L include Atypical Autism and Osteoarthritis. Among its related pathways are p75 NTR receptor-mediated signalling and Phospholipase-C Pathway.

Molecular Weight: 125kD

Gene ID: 23263

UniProt: O15068

Pathways: Neurotrophin Signaling Pathway, Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis