MAP3K14 antibody (AA 90-170)

Catalog No. ABIN7229494

The Rabbit Polyclonal anti-MAP3K14 antibody is suitable to detect MAP3K14 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for MAP3K14 antibody (AA 90-170) (ABIN7229494)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MAP3K14 Antibody

Binding Specificity: AA 90-170

Purpose: Rabbit Anti-M3K14 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of M3K14 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human M3K14 protein at AA range: 90-170

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Alternative Name: M3K14

Background: Mitogen-activated protein kinase kinase kinase 14, NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIKMAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. MAP3K14 is a Protein Coding gene. Diseases associated with MAP3K14 include Nik Deficiency. Among its related pathways are 4-1BB Pathway and RANK Signaling in Osteoclasts.

Molecular Weight: 104kD

Gene ID: 9020

UniProt: Q99558

Pathways: NF-kappaB Signaling, TCR Signaling