MLK1/2 antibody

Catalog No. ABIN7222486

This Rabbit Polyclonal antibody specifically detects MLK1/2 in IHC, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for MLK1/2 antibody (ABIN7222486)

Target: MLK1/2

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLK1/2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-MLK1/2 Antibody

Purpose: Rabbit Anti-MLK1/2 Polyclonal Antibody

Specificity: MLK1/2 Polyclonal Antibody detects endogenous levels of MLK1/2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human MLK1/2 around the non-phosphorylation site of T312/266

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MLK1/2

Target: MLK1/2

Background: MAP3K9, MLK1, PRKE1, Mitogen-activated protein kinase kinase kinase 9, Mixed lineage kinase 1, MAP3K10, MLK2, MST, Mitogen-activated protein kinase kinase kinase 10, Mixed lineage kinase 2, Protein kinase MSTThe protein encoded by MAP3K10 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Gene ID: 4293, 4294

UniProt: P80192, Q02779