MLL2 antibody (AA 1430-1510)

Catalog No. ABIN7229696

The Rabbit Polyclonal anti-MLL2 antibody is suitable to detect MLL2 in samples from Human and Mouse. It has been validated for IHC and IF.

Quick Overview for MLL2 antibody (AA 1430-1510) (ABIN7229696)

Target: MLL2 (Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MLL2 Antibody

Binding Specificity: AA 1430-1510

Purpose: Rabbit Anti-MLL2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MLL2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MLL2 protein at AA range: 1430-1510

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MLL2

Target: MLL2 (Myeloid/lymphoid Or Mixed-Lineage Leukemia 2 (MLL2))

Alternative Name: MLL2

Background: Histone-lysine N-methyltransferase 2D, Lysine N-methyltransferase 2D, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. The protein encoded by KMT2D is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in KMT2D have been shown to be a cause of Kabuki syndrome.

Molecular Weight: 609kD

Gene ID: 8085

UniProt: O14686

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Warburg Effect