MYO3A antibody (AA 180-260)

Catalog No. ABIN7229858

This Rabbit Polyclonal antibody specifically detects MYO3A in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for MYO3A antibody (AA 180-260) (ABIN7229858)

Target: MYO3A (Myosin IIIA (MYO3A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYO3A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-MYO3A Antibody

Binding Specificity: AA 180-260

Purpose: Rabbit Anti-MYO3A Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MYO3A protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MYO3A protein at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MYO3A

Target: MYO3A (Myosin IIIA (MYO3A))

Alternative Name: MYO3A

Background: Myosin-IIIaMYO3A (Myosin IIIA) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Actin Nucleation by ARP-WASP Complex. The protein encoded by MYO3A belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of MYO3A is highly restricted, with the strongest expression in retina and cochlea.

Molecular Weight: 177kD

Gene ID: 53904

UniProt: Q8NEV4

Pathways: Sensory Perception of Sound, Phototransduction