NEURL antibody (AA 190-270)

Catalog No. ABIN7225840

The Rabbit Polyclonal anti-NEURL antibody is suitable to detect NEURL in samples from Human and Mouse. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for NEURL antibody (AA 190-270) (ABIN7225840)

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEURL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NEURL Antibody

Binding Specificity: AA 190-270

Purpose: Rabbit Anti-Neuralized-1 Polyclonal Antibody

Specificity: Neuralized-1 Polyclonal Antibody detects endogenous levels of Neuralized-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Neuralized-1 at AA range: 190-270

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NEURL

Target: NEURL (Neuralized Homolog (Drosophila) (NEURL))

Alternative Name: Neuralized-1

Background: NEURL, NEURL1, NEURL1A, RNF67, Neuralized-like protein 1A, h-neu, h-neuralized 1, RING finger protein 67NEURL1B (neuralized homolog 1B), also known as neur2 or NEURL3, is a 555 amino acid protein that functions as an E3 ubiquitin-protein ligase. Involved in protein ubiquitination, NEURL1B contains two NHR (neuralized homology repeat) domains and one RING-type zinc finger. NEURL4 (neuralized homolog 4 (Drosophila)), also known as neuralized-like protein 4, is a 1,562 amino acid protein that is highly expressed in a wide variety of tissues. Containing six NHR (neuralized homology repeat) domains, NEURL4 exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 17p13.1.

Molecular Weight: 62kD

Gene ID: 9148

UniProt: O76050

Pathways: Notch Signaling, EGFR Signaling Pathway