OXT antibody (Internal Region)

Catalog No. ABIN7222882

This Rabbit Polyclonal antibody specifically detects OXT in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Rat.

Quick Overview for OXT antibody (Internal Region) (ABIN7222882)

Target: OXT (Oxytocin, Prepropeptide (OXT))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OXT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-OXT Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-Neurophysin I Polyclonal Antibody

Specificity: Neurophysin I Polyclonal Antibody detects endogenous levels of Neurophysin I protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Neurophysin I

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for OXT

Target: OXT (Oxytocin, Prepropeptide (OXT))

Alternative Name: Neurophysin I

Background: OXT, OT, Oxytocin-neurophysin 1, OT-NPIOXT encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

Molecular Weight: 19kD

Gene ID: 5020

UniProt: P01178

Pathways: Myometrial Relaxation and Contraction, Feeding Behaviour