PSPC1 antibody (AA 10-90)

Catalog No. ABIN7230818

The Rabbit Polyclonal anti-PSPC1 antibody (ABIN7230818) specifically detects PSPC1 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PSPC1 antibody (AA 10-90) (ABIN7230818)

Target: PSPC1 (Paraspeckle Component 1 (PSPC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSPC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PSPC1 Antibody

Binding Specificity: AA 10-90

Purpose: Rabbit Anti-PSPC1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PSPC1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PSPC1 protein at AA range: 10-90

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PSPC1

Target: PSPC1 (Paraspeckle Component 1 (PSPC1))

Alternative Name: PSPC1

Background: Paraspeckle component 1, Paraspeckle protein 1PSPC1 (Paraspeckle Component 1) is a Protein Coding gene. Diseases associated with PSPC1 include Eec Syndrome and Rapp-Hodgkin Syndrome. Among its related pathways are Circadian rythm related genes. PSPC1 encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by PSPC1 is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of PSPC1 results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.

Molecular Weight: 57kD

Gene ID: 55269

UniProt: Q8WXF1