PREX1 antibody (AA 340-420)

Catalog No. ABIN7230776

The Rabbit Polyclonal anti-PREX1 antibody (ABIN7230776) specifically detects PREX1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for PREX1 antibody (AA 340-420) (ABIN7230776)

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PREX1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PREX1 Antibody

Binding Specificity: AA 340-420

Purpose: Rabbit Anti-PREX1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PREX1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PREX1 protein at AA range: 340-420

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PREX1

Target: PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1))

Alternative Name: PREX1

Background: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, P-Rex1, PtdIns(3,4,5)-dependent Rac exchanger 1PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) is a Protein Coding gene. Diseases associated with PREX1 include Luminal Breast Carcinoma. Among its related pathways are p75 NTR receptor-mediated signalling and RET signaling. The protein encoded by PREX1 acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

Molecular Weight: 182kD

Gene ID: 57580

UniProt: Q8TCU6

Pathways: Regulation of Actin Filament Polymerization