PDE10A antibody (AA 40-120)

Catalog No. ABIN7219164

This Rabbit Polyclonal antibody specifically detects PDE10A in WB, ELISA and IHC. It exhibits reactivity toward Human and Rat.

Quick Overview for PDE10A antibody (AA 40-120) (ABIN7219164)

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE10A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PDE10A Antibody

Binding Specificity: AA 40-120

Purpose: Rabbit Anti-PDE10A Polyclonal Antibody

Specificity: PDE10A Polyclonal Antibody detects endogenous levels of PDE10A protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human PDE10A at AA range: 40-120

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PDE10A

Target: PDE10A (phosphodiesterase 10A (PDE10A))

Alternative Name: PDE10A

Background: PDE10A, cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10AThe phosphodiesterase 10A encoded by PDE10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for PDE10A.

Molecular Weight: 75kD

Gene ID: 10846

UniProt: Q9Y233

Pathways: cAMP Metabolic Process