PNKP antibody (AA 50-130)

Catalog No. ABIN7230720

The Rabbit Polyclonal anti-PNKP antibody (ABIN7230720) specifically detects PNKP in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for PNKP antibody (AA 50-130) (ABIN7230720)

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNKP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PNKP Antibody

Binding Specificity: AA 50-130

Purpose: Rabbit Anti-PNKP Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PNKP protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PNKP protein at AA range: 50-130

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PNKP

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Alternative Name: PNKP

Background: Bifunctional polynucleotide phosphatase/kinase, DNA 5'-kinase/3'-phosphatase, Polynucleotide kinase-3'-phosphatase, Polynucleotide 3'-phosphatase, 2'(3')-polynucleotidase, Polynucleotide 5'-hydroxyl-kinasePNKP (Polynucleotide Kinase 3'-Phosphatase) is a Protein Coding gene. Diseases associated with PNKP includeAtaxia-Oculomotor Apraxia 4andMicrocephaly, Seizures, And Developmental Delay. Among its related pathways areDNA DamageandDNA damage_NHEJ mechanisms of DSBs repair.

Molecular Weight: 57kD

Gene ID: 11284

UniProt: Q96T60

Pathways: DNA Damage Repair, Nucleotide Phosphorylation